Value of ligating the middle colic artery from the root in radical surgical treatment of right hemicolon cancer / 中华胃肠外科杂志

<p><b>OBJECTIVE</b>To compare the long-term outcome of ligating the middle colic artery in radical surgical treatment of right hemicolon cancer.</p><p><b>METHODS</b>The operation safety, complications and short-term outcome between two groups of patients undergone either ligating the middle colic artery from its root (A group) or ligating the middle colic artery from its right branch (B group) in right hemicolectomy for colon cancer.</p><p><b>RESULTS</b>Between January 1981 and December 2004, 308 patients underwent radical right hemicolectomy in which 103 patients were treated by ligating the middle colic artery from its roots(Jan. 1996 to Dec. 2004, A group), and 205 patients via ligating the middle colic artery from the roots of its right branch(Jan. 1981 to Dec. 1995, B group). The complications were compared between the two groups(P>0.05). The mean follow-up time of A and B group were(50.1+/-7.2) months and(49.1+/-7.2) months respectively. Local recurrences of 1-year, 3-year and cumulative survival probability at the 60th month in group A were 1.9%, 13.6% and(78.3+/-3.4)% respectively, which were significantly better than 19.0%, 24.9% and(64.8+/-2.8)% in group B(P<0.05).</p><p><b>CONCLUSION</b>Ligating the middle colic artery from its root in right hemicolectomy can be performed safely and effectively, which is to be highly recommended in curative resection of right colon.</p>

Expression of Ezrin in gastric carcinoma and its significance / 中华胃肠外科杂志

<p><b>OBJECTIVE</b>To investigate the expression of Ezrin in gastric cancer, its role in tumor metastasis.</p><p><b>METHODS</b>Ezrin expression in tumor tissues from 90 gastric cancer cases and in normal gastric mucosa from 12 cases with benign disease was examined by immunohistochemical staining. Ezrin expression in gastric cancer cell lines was also detected by Western blot, and in vitro invasion assay was used to examine the invasive ability of the cell lines.</p><p><b>RESULTS</b>The expression rate of Ezrin was significantly higher in gastric cancer tissues than that in normal tissues (P< 0.05), and significantly correlated with lymph node metastasis (P< 0.05). Western blot showed that MKN-45 cell line had the highest expression of Ezrin among 5 gastric cancer cells. MKN-45 possessed highest invasion ability.</p><p><b>CONCLUSION</b>Ezrin expression is up-regulated, and may be associated with lymph node metastasis in gastric cancer.</p>